2015 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Bio-X
Mentor: Matthew Porteus, Pediatrics

Sickle cell disease (SCD) is a genetic disease affecting millions worldwide, in which mutant hemoglobin causes blood cells to become very rigid and hamper blood flow or even cell destruction. Joab will be looking at ways to optimize gene editing in hematopoietic stem cells (HSPCs) to combat SCD since gene edited HSPCs may be a potential cure for sickle cell disease. Joab's summer project, therefore, will entail testing one hypothesis that might increase the frequency of gene correction as a step towards potentially curing SCD.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 26, 2015:

Optimizing HR of HBB Locus Using CRISPR/Cas9 and RAAV6 in HPSCs

Joab Camarena1, Daniel Dever1, Ayal Hendel1, Matthew Porteus1
[Department of Pediatrics1, Stanford University]