Dr. Pollack's laboratory uses genomic approaches to investigate the pathogenesis and biology of human cancer, and to identify strategies for improved cancer diagnosis, prognostication and patient management. Technologies include DNA microarrays, deep sequencing, and RNAi screens, and additional insight is provided by the biocomputational integration of different data types.

Active areas of investigation include:

1. Characterizing molecular subtypes of prostate cancer to identify biomarkers for risk-assessment
2. Identifying recurrent DNA copy number alterations and rearrangements in common epithelial tumor types (e.g. breast, prostate, lung, colon, and pancreatic cancers) to discover new cancer genes
3. Understanding the role of altered chromatin remodeling and "lineage-dependent" oncogenes in tumorigenesis
4. Investigating mechanisms underlying genomic instability and the shaping of cancer genomes.