Home Department: Biology
Mentor: Daniel Jarosz (Chemical & Systems Biology and Developmental Biology)

“Role of ER-Mitochondria Contact Sites in Proteostasis”

Jordan will work with mentors on modeling the biological mechanisms of protein maintenance at the Endoplasmic Reticulum (ER)-mitochondria contact sites. They will do experiments on the Baker's yeast model organism to uncover potential mechanisms of regulating protein stress. They will use proximity labeling enzymes and mass spectrometry to assess the protein composition at the contact sites with and without stress to identify which proteins become active or inactive under stress conditions. In parallel, they will run experiments to identify the activity at the contact sites under various models of stress. They will pool their data from these experiments to delineate which of several potential models are valid and identify key next steps in their pursuit to understand how protein structure and function are maintained under stress.