The Goronzy lab is interested in understanding how a functional immune system is maintained with age, despite failing regenerative capacity and accumulating impacts by challenges from exogenous and latent infections. They study mechanisms, at the system as well as the single cell level, that contribute to declining immunity and to the higher frequency of some autoimmune diseases with age. They primarily work with human blood specimens or cell lines. Ultimately, they are trying to identify molecular pathways that can be targeted to improve immune function in advanced age.