Home Department: Biology
Mentor: Kristy Red-Horse, Biology

“Single-Cell RNA Sequencing of Coronary Vascular Endothelial Cells at Neonatal Stages”

Coronary artery disease (CAD) obstructs essential blood flow to the heart and results in mortality or severe injury. In contrast to the adult heart, the neonatal mouse heart, including its coronary arteries, has a unique capacity to repair itself after injury. Josephine aims to characterize the neonatal heart’s regenerative potential by using single-cell RNA sequencing techniques to investigate differences in gene expression between vascular endothelial cells at different neonatal stages. Understanding neonatal coronary artery development may contribute to the greater goal of repairing coronary arteries in the diseased adult heart.