Headshot portrait of Julien Sage - Professor of Pediatrics (Hematology/Oncology) and of Genetics
Bio-X Affiliated Faculty

Dr. Sage's research program focuses on the mechanisms that control the proliferation of mammalian cells under normal and pathological conditions (regeneration, cancer), with a particular emphasis on stem cells and gene regulatory networks. They combine genetic, genomics, and proteomics approaches to identify and investigate genes and pathways involved in cancer initiation and progression. The lab uses genome-editing strategies to develop and study genetically-engineered mouse models for human cancers, including lung cancer, pancreatic cancer, and liver cancer. Their work spans the investigation of fundamental biological processes to the implementation of clinical trials based on our findings in pre-clinical models.