Headshot portrait of Jun Ding - Associate Professor of Neurosurgery and of Neurology
Bio-X Affiliated Faculty

Dr. Jun Ding's lab is interested in the interplay between motor cortex, sensory cortex, thalamus and basal ganglia is essential for neural computations involved in generating voluntary movements. Their goal is to dissect the functional organization of motor circuits, particularly cortico-thalamo-basal ganglia networks, using electrophysiology, 2-photon microscopy, optogenetics, and genetic tools. The long-term scientific goal of the lab is to construct functional circuit diagrams and establish causal relationships between activity in specific groups of neurons, circuit function, animal motor behavior and motor learning, and thereby to decipher how the basal ganglia process information and guide motor behavior. They will achieve this by investigating the synaptic organization and function that involve the cortex, thalamus and basal ganglia at the molecular, cellular and circuit level. Currently, the Ding lab is focusing on several questions:

  • How are excitatory and inhibitory inputs integrated in the striatum?
  • How do feed-forward and recurrent local inhibitions balance the excitation in the striatum?
  • How are functional maps modulated in motor behavior and motor learning?

The Ding lab's goal is to bridge the gap between molecular or cellular events and the circuit mechanisms that underlie motor behavior. In addition, they aim to further help construct the details of psychomotor disorder ‘circuit diagrams,’ such as the pathophysiological changes in Parkinson’'s disease.