2014 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: anonymous donor
Mentor: Matthew Scott, Developmental Biology and Genetics

Karthik Ramasubramanian's research in Dr. Matthew Scott's lab focuses on the genetic underpinnings of Niemann-Pick type C disease, a fatal lysosomal storage disease that causes progressive neurodegeneration due to mutations in the npc1 gene. Specifically, he is utilizing the genetics of the model organism Drosophila melanogaster to study possible genetic suppressors of the mutated Npc1 protein, such as Arfgef (a class of guanine nucleotide exchange factors), and their effect on endoplasmic reticulum reorganization in somatic cells.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 27, 2014:

Take Your 'Pick': Using D. melanogaster Genetic Screens to Understand the Relationship Between NPC1 and ER Reorganization in Niemann-Pick, Type C Disease

Karthik Ramasubramanian1, Luis A. Milla1, Matthew P. Scott1,2,3
[Departments of Developmental Biology1, Genetics2, and Bioengineering3, Stanford University]