2017 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Anonymous Donor
Mentor: Steven Chang, Neurosurgery

Cerebral arteriovenous malformations (AVMs) are poorly understood, yet potentially devastating lesions of cerebral vasculature that can lead to high feeding artery pressures, venous drainage, and other hemodynamic abnormalities such as hemorrhages, migraines, or seizures. Using an endothelial cell tube-formation assay that is currently well-established in the lab for studying tube formation and vessel dilation during development, Ketan will work to quantify and describe the relationship between the microenvironment and abnormal vasculature development present in the progression of AVMs, as well as develop an in vitro model for studying the disease.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Characterization of Novel Cell Lines Isolated from Human Brain Arteriovenous Malformations (AVMs)

Ketan Jain-Poster1, Lorelei Shoemaker1, Breanna Allen1, Steven Chang1
[Department of Neurosurgery1, Stanford University]