Bio-X Graduate Student Fellow

Awarded in 2007
Home Department: Materials Science & Engineering
Faculty Advisors: Sarah Heilshorn (Materials Science & Engineering) and Andrew Spakowitz (Chemical Engineering)

Research Description: The goal of Larry’s research project was to understand the structural and behavioral characteristics of quaternary protein structure using the coat-vesicle protein clathrin. This study employed two major approaches in parallel: development of a theoretical model using Brownian dynamics simulation to predict quaternary structure and in vitro self-assembly experiments to observe and control the quaternary structure. Clathrin proteins perform their biological functions by self-assembling into cages, and recent reports have begun to elucidate the structure of the individual clathrin molecule and have provided a more detailed static picture of the in vivo assembly.


Larry is a launch program manager at Pebble Technology.