2015 Undergraduate Summer Research Program Participant

Home Department: Biomedical Computation
Supported by: Bio-X
Mentor: Yoon-Jae Cho, Neurology

Lauren's project focuses on how chemical modifications of the genome ("epigenome") influence the initiation and maintenance of medulloblastoma, the most common malignant pediatric brain tumor. She aims to employ wet-bench experiments in conjunction with machine learning techniques to analyze specific epigenetic states of medulloblastoma at each phase of cerebellar development. Identifying differences between the basal epigenetic state of medulloblastoma and normal development will unveil potential avenues for therapy.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 26, 2015:

Targeting Epigenetic Repression to Induce Neural Differentiation in Medulloblastoma

Lauren Ellis1, James Purzner2, Matthew Scott2, Yoon-Jae Cho1
[Departments of Neurology1 and Developmental Biology2, Stanford University]