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Lawrence Bai - Bio-X Bowes Fellow

Bio-X Graduate Student Fellow

Awarded in 2019
Home Department: Immunology
Faculty Advisors: Aida Habtezion (Medicine - Gastroenterology & Hepatology), Purvesh Khatri (Medicine - Biomedical Informatics and Biomedical Data Science) , and Paul (PJ) Utz (Medicine - Immunology and Rheumatology)

Research Title: Elucidating the Role of Epigenetic Modifications in IBD Pathogenesis and Presentation Using Mass Cytometry

Research Description: Inflammatory bowel disease (IBD), which includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), impacts 3 million US adults and is increasing in incidence. Despite significant associations between IBD and genetics,Photo of graduate student Lawrence Bai in a dry lab, working on a computer showing brightly-colored 3D images. diet, and the microbiome, its etiology remains unknown. Epigenetics, or the study of non-genetic modifications to the organism’s gene expression, potentially links all three factors but has not been thoroughly studied in IBD. Using a novel single-cell technology, EpiTOF, Lawrence will study the epigenetics of immune cells from patients with IBD using state-of-the-art analytic methods to better understand and identify epigenetic differences in IBD pathology, which could ultimately lead to development of novel and effective therapies for patients with IBD.

WHERE IS HE NOW?

Lawrence is a Life Sciences Specialist at LEK Consulting, where he is working on a variety of strategy-focused projects in the life sciences industry.