Bio-X SIGF Graduate Student Fellow

Awarded in 2018
Home Department: Bioengineering
Faculty Advisors: Joseph Woo (Cardiothoracic Surgery) and Eric Appel (Materials Science & Engineering)

Research Title: Post-Operative Adhesion Prevention Using Polymer Nanoparticle Hydrogels

Research Description: Adhesions are fibrous bands of scar tissue forming between internal organs and tissues following any type of surgery in any part of the body, Photo of graduate student Lyndsay Stapleton in the lab, using a microscope.with incidence rates approaching 95%. These adhesions have numerous side effects ranging from extreme pain to increased risks during secondary and tertiary operations. Current adhesion barrier technologies are only indicated for use in the abdomen. Moreover, they are used in less than 10% of abdominal surgeries due to rapid degradation, difficulty handling during surgery, and becoming dislodged in the body. Lyndsay’s goal is to develop a transformational approach to prevent adhesions that result from cardiothoracic surgery by bringing together material science, bioengineering, and cardiovascular medicine to treat post-operative adhesions.


Lyndsay is an Associate Director of Corporate Development at Calcilytix Therapeutics, a BridgeBio company.