Dr. Davis's lab is interested in the molecular basis of T and B lymphocyte recognition, as well as the control of differentiation and functional responses in these cells. These studies have ranged from analyzing the inherent diversity of these highly diverse molecules and relating it to their function and specificity, to basic aspects of TCR biochemistry and cell biology. They also developed peptide-MHC tetramers which are useful for staining and isolating specific T cells in both basic science and clinical applications.