Dr. Mark Holodniy specializes in the treatment of infectious diseases with an expertise in the care of patients with HIV or HCV infections. He maintains broad investigative programs in the field of infectious diseases, encompassing clinical trials, surveillance for emerging infections, and translational correlates. He is the Principal Investigator on numerous clinical trials. He is the Director of the Public Health Surveillance & Research Program and Public Health Reference Laboratory for the Department of Veterans Affairs and serves as Editor-in-Chief for the journal Diagnostic Microbiology and Infectious Disease.

Dr. Holodniy's research program is currently focused in three areas:

1. translational research (HCV/HIV viral evolution and antiviral resistance prevalence and development),
2. HIV/HCV clinical trials (diagnostic assay/medical device, antiretrovirals, ARVs and immunomodulators), and
3. health services research focusing on cost effectiveness of HIV antibody and ARV resistance testing and ARV utilization and clinical outcome.