Bio-X Graduate Student Fellow

Awarded in 2015
Home Department: Mechanical Engineering
Faculty Advisors: Constance Chu (Orthopaedic Surgery), Thomas Andriacchi (Mechanical Engineering, Orthopaedic Surgery), Garry Gold (Radiology), and William Robinson (Medicine - Immunology & Rheumatology)

Research Title: Biomechanical, biological, and structural interaction in the development of osteoarthritis following anterior cruciate ligament reconstructive surgery”

Research Description: One in nine Americans suffer from osteoarthritis (OA), a debilitating joint disease Photo of Matthew Titchenal.characterized by pain, swelling, and thinning of joint cartilage. Its symptoms are not present early in the disease, so it’s usually diagnosed after already reaching an irrecoverable advanced state. Anterior cruciate ligament (ACL) tear greatly accelerates the development of knee OA, and reconstructive surgery has not been successful in preventing it. Matt’s project integrates methods in biomechanics, imaging, and joint biology to study early events leading to OA following ACL reconstruction, with the ultimate goal of developing clinical methods for early detection and prevention of OA, when disease modification is still feasible.


Matthew is continuing his post-graduate career as a technical consultant at InSciTech in Mountain View, California.