Dr. Zeineh's research work and interests are driven by the challenge to noninvasively characterize the microscopic pathology underlying neurologic disease, particularly disease entities with a significant component of pathology invisible to conventional imaging methods. Specifically, Dr. Zeineh utilizes high-field MRI, advanced susceptibility based processing, and diffusion tensor imaging, as well as other novel contrast mechanisms, with the following applications:

1. MR imaging and characterization of amyloid plaques in the brains of Alzheimer’s patients;
2. early in vivo biomarker imaging for Alzheimer’s disease;
3. improved imaging of seizure foci in localization-related epilepsy;
4. identifying network derangements and microstructural alterations in Parkinson’s disease;
5. imaging biomarkers for multiple sclerosis with quantitative imaging (measurement of myelin content);
6. general applications of ultra-high field MRI for neurologic disease.