Home Department: undeclared
Mentor: Thomas Quertermous (Medicine - Cardiovascular Medicine)

“Establishing the Lineage of Arterial Intimal Macrophages”

The Quertermous laboratory has mapped genes that contribute to coronary artery disease (CAD) genetic risk and employed single-cell RNA sequencing with mouse disease model tissues to study the functional role of these genes. Through this work, vascular cell phenotypic transitions and new cellular identities have been characterized, but the localization and movement of these cells during disease progression are unknown. Nathan is using RNA in situ hybridization of transition cell marker genes to characterize where these novel cells arise and what their relationship is to vascular structures.