2012 and 2010 Undergraduate Summer Research Program Participant

Home Department: Bioengineering
Supported by: Steve Krausz and Marisa Arredondo
Mentor: Josh Elias, Assistant Professor of Chemical & Systems Biology

Nick Davis is a rising senior in the bioengineering honors program at Stanford. He is conducting his honors project in the Josh Elias Laboratory. In his research he seeks to apply desorption electrospray ionization (DESI), a mass spectrometry technique that he had previously developed to study transition-metal-catalyzed reactions, to monitor enzymatic reactions in real time. The ability to study kinase and phosphatase interactions on substrates and to observe product formation in real time with DESI could prove valuable to the burgeoning fields of top-down proteomics and protein engineering. Nick plans to pursue a PhD program in Bioengineering.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 27, 2012:

Probing Enzymatic Reactions with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)

Nick Davis1, Joshua Elias2
[Departments of Bioengineering1and Chemical & Systems Biology2, Stanford University]

Home Department: Bioengineering
Supported by: Bio-X
Mentor: Richard N. Zare, Professor of Chemistry and of Physics

Nick Davis is beginning his sophomore year as a Bioengineering major and Chemistry minor. He hopes to further introduce the quantitative methods employed in chemistry to the fields of bioengineering and medicine. This summer, he is working on a project under Professor Richard Zare. For the first time ever, with Dr. Richard Perry, Nick has detected reaction intermediates in a ruthenium-catalyzed hydrogenation reaction via desorption electrospray ionization mass spectrometry (DESI-MS). The next line of attack in Nickʼs research is probing transition-metal-catalyzed and organocatalytic reactions by DESI. Nick foresees the DESI method as a promising ambient technique for the study of reaction dynamics at a fundamental level.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 25, 2010:

A Platform for the Shearing of Cell Monolayers

Nick Davis, Richard H. Perry, Maurizio Splendore, Allis Chien, Richard N. Zare
[Bioengineering, Materials Science, Chemistry; Stanford University]