The Huang group's research combines both computational and experimental aspects of protein engineering. The protein design field took ten years to find a foothold in designing de novo structures (i.e. achieving full control of modeling protein backbones and sequences) and finally matured, as suggested by the recent wave of publications, such that we are now closer to achieving atomic-precision design of custom-made protein structures to address biomedical problems. Many challenges remain, as we are still far from achieving the complexity and functionality that nature displays. Dr. Huang's lab is building a strong interdisciplinary research program to bridge this gap.