Headshot portrait of Ryoko Hamaguchi - Bio-X Undergraduate Fellow
2014 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Dean of Research
Mentor: Sean Wu, Medicine (Cardiovascular Medicine)

Ryoko Hamaguchi is using human induced pluripotent cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro model to investigate the mechanisms of doxorubicin-induced cardiotoxicity. Her project focuses specifically on how doxorubicin, a common chemo-therapeutic agent, affects processes governing intracellular and mitochondrial iron levels in heart cells.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 27, 2014:

An In Vitro Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model Reveals Alterations in Iron Metabolism in Doxorubicin-Induced Cardiotoxicity

Ryoko Hamaguchi1,2,3,4, Arun Sharma1,2,3,4, Paul Burridge1,2,3,5, Joseph C. Wu1,2,3,4,5, Sean M. Wu1,2,3
[Departments of Medicine (Division of Cardiology)1, Biology4, and Radiology5, Institute for Stem Cell Biology & Regenerative Medicine2, and Stanford Cardiovascular Institute3, Stanford University]