2017 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Bio-X
Mentor: Lucy O’Brien, Molecular & Cellular Physiology

In healthy organs, a network of differentiated cells—collectively called the ‘niche’—directs stem cells on when to properly divide. When stem cells become tumorigenic, they stop listening to directions given by their niche; currently, little is known about how this mechanism works. Using the fruit fly intestinal tract as a model, Sang is looking at how manipulating key factors in the cell division pathway influences tumor development.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Appropriation of Tissue Renewal Signals Drives Development of Intestinal Stem Cell Adenomas

Sang Ngo1, Jackson Liang2, Lucy O’Brien1
[Department of Molecular & Cellular Physiology1, Stanford University; Genentech, Inc.2]