2017 Undergraduate Summer Research Program Participant

Home Department: Human Biology
Supported by: Vice Provost for Undergraduate Education
Mentor: Frederick Chin, Radiology

Photo of USRP student Scarlett Guo in the lab, putting samples into a large piece of equipment.Fragile X syndrome is a neurodevelopmental disorder caused by a mutation in the FMR1 gene. The disorder is characterized by abnormal body features and sensitivity to stimuli as well as intellectual, emotional, and behavioral disabilities. Through a competitive binding experiment and combined PET and MRI imaging on an established fragile X syndrome mouse model, Scarlett aims to develop a non-invasive imaging method potentially transferrable to human imaging to investigate the developmental physiology of the GABAergic neurotransmitter system at a critical stage of neurodevelopment and the onset of fragile X syndrome.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Multimodal Imaging of the FMR1 Knockout Mouse: A Model of Fragile X Syndrome

Scarlett Guo1, Samantha Reyes1, Bin Shen1, Shawn Scatliffe1, Jun Hyung Park1, Zheng Miao1, Jessa Castillo1, Sanaz Mohajeri1, Meng Gu1, Christoph Leuze1, Frederick T. Chin1
[Department of Radiology1, Stanford University]