2016 Undergraduate Summer Research Program Participant

Home Department: Management Science & Engineering
Supported by: Vice Provost for Undergraduate Education
Mentor: William Talbot, Developmental Biology

Photo of USRP student Scott Fleming in the lab, examining a dish of samples under a microscope.Microglia are specialized immune cells that regulate inflammation in the central nervous system (CNS) of vertebrates and defend the brain against foreign pathogens. Using targeted gene-editing techniques, Scott will investigate the mechanism by which a recently discovered protein in microglia, NLRC3-like, protects the CNS from inappropriate hyperinflammation. A better understanding of NLRC3-like and the inflammation pathway has important implications for diseases associated with neuroinflammation, such as Parkinson’s disease and Alzheimer’s disease.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2016:

Mechanistic Investigation of Inflammation Regulation by Novel Protein NLRC3-like

Scott L. Fleming1, Ana Meireles Sousa1, William S. Talbot1
[Department of Developmental Biology1, Stanford University]