Home Department: undeclared
Mentor: Avnesh Thakor (Radiology)

“Enhancing Therapeutic Efficacy in Pediatric Inflammatory Bowel Disease”

In children, inflammatory bowel disease (IBD) poses a significant health challenge, necessitating targeted therapies. Shayaan’s project proposes using mesenchymal stem/stromal cells (MSCs) derived from the umbilical cord, specifically primed with pulsed-focused ultrasound, to address the immune dysregulation and bioenergetic deficits in pediatric IBD. The study aims to optimize the priming process, evaluate therapeutic efficacy in vitro, and compare the outcomes of conventional intravenous administration with a novel intra-arterial approach in juvenile rats with colitis. The goal is to enhance treatment precision, reduce inflammation, and promote tissue regeneration, offering a promising avenue for urgently needed therapies in pediatric IBD.