Headshot portrait of Sierra Lore - Bio-X Undergraduate Fellow
2021 Undergraduate Summer Research Program Participant

Home Department: Biology
Mentor: Chaitan Khosla (Chemical Engineering and Chemistry)

“Quantification of Immunogenic Peptides from Dietary Gluten in the Urine of Patients with Celiac Disease”

Through peptidomics analysis, the Khosla lab has identified candidate biomarkers that distinguish patients with celiac disease from healthy controls. The lab is interested in designing a quick, inexpensive immunoassay that predicts the health status of patients with CeD. Through peptide synthesis and site-selective chemical modification, Sierra is developing an immunoassay that measures the amount of peptide biomarkers that the lab has previously found. She will then assess the correlation between the concentrations of peptide biomarkers and celiac disease status using de-identified clinical data.