Inadequate removal of uremic solutes contributes to widespread illness in the more than 500,000 Americans maintained on dialysis. But researchers know remarkably little about these solutes. Dr. Timothy Meyer's research efforts are focused on identifying which uremic solutes are toxic, how these solutes are made, and how their production could be decreased or their removal could be increased. Dr. Meyer's group hopes to improve treatment by finding out more about what we are trying to remove.