2017 Undergraduate Summer Research Program Participant

Home Department: undeclared
Supported by: Bio-X
Mentor: Kim Butts Pauly, Radiology

Antibodies and immunotherapy show promise in shrinking malignant brain tumors. However, the blood brain barrier (BBB), a protective filtration system of blood vessels, only allows molecules of certain sizes to pass, and these antibodies are almost 400 times too large to pass through and attack the tumor. Victoria is exploring the application of focused ultrasound to open the BBB for antibody transport, then analyzing the activity of antibodies as they target brain tumors.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Kinetics of Contrast Agents Extravasation Across the Blood Brain Barrier After Focused Ultrasound Opening

Victoria Yuan1,2, Aurea Pascal-Tenorio1,2, Kim Butts Pauly1,2
[Department of Radiology1 and Radiological Sciences Laboratory2, Stanford University]