Home Department: Biology
Supported by: Dean of Research
Mentor: Manish Butte, Pediatrics

Yoseph is studying a possible mechanism behind diseases where the immune response is too weak or too strong in fighting infections. He is particularly looking at the effect of a major enzyme (αTAT1) in T cell activation and proliferation. He will do this by comparing strength of the initial T cell activation signals, the organization of part of the complex signaling structure, and the response to infection between regular mice and those lacking the enzyme.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 26, 2015:

The Role of Spectrin in T Cell Stiffness and Signaling

Yoseph Semma¹, Kenneth Hu², Manish Butte³
[Departments of Biology¹, Biophysics², and Pediatrics³, Stanford University]