Bio-X SIGF Graduate Student Fellow

Awarded in 2020
Home Department: Bioengineering
Faculty Advisors: Bo Wang (Bioengineering) and James Ferrell (Chemical & Systems Biology and Biochemistry)

Research Title: Wound-Induced Trigger Waves to Coordinate Tissue- Wide Regeneration Response

Research Description: Yuhang aims to understand the rapid wound signal transduction in tissues that enables regeneration. The central working hypothesis is that wound signals propagate in the form of trigger waves induced by a positive feedback loop between extracellular signaling proteins and epidermal growth factor receptors. Yuhang will study the planarian, a highly regenerative animal, as the model system, and combine novel sequencing technology, functional genomics analysis, and computational modeling to quantify wound signal propagation, construct core regulatory genetic circuits, and model intercellular trigger wave dynamics. This work will help elucidate the fundamental rules that enable the rapid cell-cell communication and the collective stress response that are essential to tissue regeneration.


Yuhang is a postdoctoral scholar at University of Chicago.