Home Department: Chemistry
Supported by: Victoria Reed
Mentor: James Chen, Chemical & Systems Biology and Developmental Biology

Zachary will be investigating the Hedgehog signaling pathway, a pathway which, when defective, can be responsible for extreme cell proliferation. Abberant Hedgehog-activated cellular growth can ultimately result in a number of cancers, including basal cell carcinoma, medulloblastoma, and meningioma. Zachary will be responsible for the development of potent inhibitors of the pathway and the characterization of their mechanisms of action.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2016:

Mechanistic Insights into a New Gli-Dependent Cancer Therapeutic

Zach Rosenthal¹, Alison Ondrus¹, Marisa Hom¹, James Chen^1,2,3
[Departments of Chemical & Systems Biology¹, Developmental Biology², and Chemistry³, Stanford University]