The Bogyo Lab is interested in developing and applying chemical tools to both image and dissect the functional roles of hydrolases in a number of human health conditions. They are currently using synthetic chemistry and biological display methods to build new covalent binding probes that allow enzyme activity to be selectively inhibited as well as imaged in complex biological samples including cells, tissues and whole organisms. The Bogyo lab is specifically interested in hydrolase enzymes important for cell signaling and pathogenesis in cancer and various microbes including S. aureus, C. difficile and gut commensal bacteria.