Membrane Transporters Beyond Crystal Structures: Dynamics and Thermodynamics of Glutamate Transporters
Frontiers in Interdisciplinary Biosciences Seminar
OLGA BOUDKER, CORNELL UNIVERSITY SCHOOL OF MEDICINE
Glutamate transporters are responsible for clearance of the neurotransmitter glutamate from the synaptic cleft following rounds of neurotransmission. They maintain steep concentration gradients of glutamate by coupling its uptake to symport of sodium ions and protons and to antiport of potassium ions. Dr. Boudker's lab has been investigating the molecular mechanism of this family of transporters.