Home Department: Biology
Supported by: Pitch and Catherine Johnson
Mentor: Joseph Wu, Medicine (Cardiovascular Medicine) and Radiology
Abhi aims to shed light on the molecular basis of familial hypertrophic cardiomyopathy by using TALEN-mediated gene editing to replace the mutant allele with the wild-type allele in patient-derived induced pluripotent stem cell (iPSC) lines. Cardiomyocytes derived from the mutant and 'corrected' iPSC lines will be analyzed using genome-wide expression profiling in order to build a molecular model of the genes and pathways associated with this disease.
Abhishek Venkataramana1, Ioannis Karakikes2, Vittavat Termglinchan2, Sebastian Diecke2, Joseph Wu2
[Departments of Biology1 and Medicine (Division of Cardiology)2, Stanford University]