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Anna Elleman - Bruce and Elizabeth Dunlevie Fellow

Bio-X SIGF Graduate Student Fellow

Awarded in 2018
Home Department: Chemistry
Faculty Advisors: Justin Du Bois (Chemistry) and John Huguenard (Neurology & Neurological Sciences)

Research Title: Understanding the role of voltage-gated sodium channels in neural hyperexcitability

Research Description: Photo of graduate student Anna Elleman in the lab, working in a tissue culture hood.Management of neuropathic pain (NP) — a condition characterized by hypersensitivity and neural hyperexcitability — costs upward of $100 billion yearly in the US. Anna intends to elucidate the regulatory pathways responsible for NP by developing neurotoxin tools that target the cellular membrane ion channels related to NP.  This project combines the tools of synthetic chemistry, electrophysiology, imaging, and neurobiology to potentially reveal new pharmaceutical targets for modulating neuronal activity and inform future efforts in the development of NP treatments.