What are the neuronal mechanisms that underlie network oscillatory synchrony in the thalamocortical system? Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy.

Dr. John Huguenard's lab's approach is an analysis of the cells and microcircuits that make up thalamic and cortical circuits. They also use computational approaches to build physiologically constrained network models to test and improve our understanding of the circuit. Accordingly, the lab has been able to identify genes whose products, mainly ion channels, play key roles in the regulation of thalamocortical network responses.

Currently, projects focus on:

• Development of excitatory connections in neocortex, with an emphasis on AMPA receptor alterations in the early postnatal period
• Molecular pharmacology of inhibitory GABA-A receptors in the thalamus, and the role of receptor phosphorylation in regulating inhibitory function
• Analysis of progression and destabilization of widespread thalamic network activity using large microelectrode arrays
• The roles of neuropeptides, especially NPY, SST, and VIP in regulating thalamic and cortical function
• Reorganization of neocortical connectivity following injury
• Roles of specific GABA-B receptors in regulating pre- and postsynaptic function.