Home Department: Bioengineering
Supported by: Vice Provost for Undergraduate Education
Mentor: Justin Annes, Medicine (Endocrinology)

All forms of diabetes, whether Type I autoimmune diabetes or Type II obesity-associated diabetes, are caused by a loss of insulin-producing beta-cells. Ben is trying to determine the three-dimensional crystal structure of an enzymatic drug target bound to an inhibitory small molecule that has been shown in prior studies to have the potential to increase beta-cell replication. If successful, the structural information will be an invaluable tool in guiding synthetic strategies for increasing potency and selectivity for the drug target.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Modeling Kinetics of GLP1R-Mediated Peptide-Based Drug Delivery

Benjamin Yeh¹, Tim Horton², Justin Annes³
[Departments of Bioengineering¹, Chemistry², and Medicine (Division of Endocrinology³), Stanford University]