Bio-X SIGF Graduate Student Fellow

Awarded in 2015
Home Department: Bioengineering
Faculty Advisors: Fan Yang (Bioengineering, Orthopaedic Surgery), Sarah Heilshorn (Materials Science & Engineering), and R. Lane Smith (Orthopaedic Surgery)

Research Title: Mimicking cartilage tissue zonal organization by engineering hydrogels with gradient niche cues”

Research Description: Osteoarthritis represents one of the most common joint degenerative diseases in the western world, affecting ~ 50% of the population above the age of 65. Photo of Danqing Zhu.Cartilage is an avascular tissue characterized by zonal organizations, which play an important role in maintaining cartilage structure and functions. There remains a critical need to develop enabling novel technologies for regenerating cartilage with tissue-mimicking zonal organization; current bottlenecks in stem cell biology and tissue regeneration cannot be addressed using the existing models and paradigms. Bonnie's proposed research will enable regeneration of cartilage with tissue-mimicking zonal structure and functions, and facilitate high-throughput screening of stem cell-niche interactions using novel gradient hydrogels.


Bonnie is an assistant professor at Hong Kong University of Science & Technology in the department of Chemical & Biological Engineering.