Home Department: Human Biology
Mentor: Melanie Hayden Gephart, Neurosurgery

“The Effect of Tumor-Immune Interactions on the Systematic Tolerance of Triple Negative Breast Cancer Brain Metastases”

Triple Negative Breast Cancer (TNBC) demonstrates high probability of spreading to the brain in cancer metastasis. The outcome of this process is often fatal, and there is a lack of FDA-approved therapies to help patients with these cancers. Immune manipulation has been associated with improved patient outcomes, but little is known about the immune interactions in TNBC. Bryanna will review clinical patient data and identify the best patients to use in this research to see how these interactions impact metastatic potential.