Dr. Mignot's current research focuses on the neurobiology, genetics and immunology of narcolepsy, a disorder caused by hypocretin (orexin) cell loss, with indirect interest in the neuroimmunology of other brain disorders.  His laboratory uses state of the art human genetics techniques, such as genome wide association, exome or whole genome sequencing in the study of human sleep and sleep disorders, with parallel studies in animal models.  His laboratory is also interested in web-based assessments of sleep disorders, computer-based processing of polysomnography (PSG), and outcomes research.

Additional research:

1. Clinical/outcome studies in various sleep disorders, with use of web based evaluation tools and geneticsHuman genetic studies in sleep disorders (GWAS, sequencing):
2. Human genetic studies in sleep disorders (GWAS, sequencing):
   • Narcolepsy.
   • Kleine Levin syndrome.
   • Rare familial syndromes with sleep disturbances.
3. Immunological and microbiomic studies in human narcolepsy and Kleine Levin syndrome.
   • Isolation of biomarkers such as autoantibodies, genome wide expression.
   • Sequencing studies of the TCR repertoire.
4. EEG signal processing analysis for automatic scoring and discovery of novel disease bio markers for neuropsychiatric disorders and clinical applications in sleep disorders medicine.
5. Genetic basis of the response to hypoxia and hypercapnia.