Home Department: Bioengineering
Mentor: Markus Covert, Bioengineering

“Curating and Modelling Gene Expression Regulation in a Whole Cell Model of E. coli”

With the rapid, independent generation of biological data by research groups worldwide, there is a pressing need to evaluate the cross-consistency of these data, extract relevant biological parameters, and integrate them into models that form our understanding of cellular processes. With E. coli as a model organism, Gaeun will curate existing parameters for gene expression and use mathematical modelling techniques to build a sub-model for gene expression regulation and subsequent translation to the protein level. This research will expand on the Covert Lab’s whole cell model of E. coli by more than 150 genes, enable predictions of cellular physiology in response to environmental changes, and contribute to an impactful pipeline that will advance the field of large-scale modelling.