Dr. Santiago's research focuses on the study of microscale transport phenomena including electrokinetic flow, electrohydrodynamic instabilities, and general convective-diffusion-electromigration processes. His research includes the optimization and development of novel micro- and nano-devices for pumping liquids, on-chip electrophoresis, sample preconcentration methods, and miniature fuel cells. The applications of this work include microfabricated bioanalytical systems for genetic analysis, drug discovery, bioweapon detection, drug delivery, and power generation.