Dr. Lars Steinmetz's lab develops genomic technologies to study the genetic basis of complex phenotypes, the mechanisms of gene regulation, and the molecular systems underpinning disease. We’re leveraging biological insights across scales and organisms to predict, diagnose, treat and ultimately prevent disease.

While technological advances have enabled the association of thousands of genetic variants to complex traits of health and disease, we lack a comprehensive understanding of how genetic variation governs phenotypic diversity and disease. This is largely due to the challenge of discovering the mechanisms through which genetic variation shape cellular phenotypes, as well as the complex interplay between variants and the impact of environmental factors. The Steimetz Lab's research is directed at developing genomics technologies and approaches to study the molecular processes that underlie complex genetic traits, gene regulation, and inherited diseases. Their approach has been to drive technology development together with biological application, in which they work across the broad axis of fundamental to translational research.