Headshot portrait of Lars Steinmetz - Professor of Genetics
Bio-X Affiliated Faculty

One of the most daunting challenges in medicine is the complex nature of most common diseases (including cancer, diabetes, and heart disease) due to interactions between multiple genetic variants and environmental influences. The Steinmetz lab's research is directed at understanding such complex traits; to do so, they develop novel genomic approaches to investigate the molecular processes that link genotype to phenotype, identify the underlying factors, and quantify their contributions. They investigate variation at the level of the genome, transcriptome and proteome, which we integrate with higher-level phenotypes. They also use the resulting molecular networks to predict and evaluate intervention points that enable modulation of phenotype.