Dr. Goldstein is Director of the Palo Alto Geriatrics Research Education and Clinical Center (GRECC) at the VA Palo Alto Health Care System and a Professor of Medicine in the Center for Health Policy/Center for Primary Care and Outcomes Research (CHP/PCOR) at Stanford University. Her area of research expertise is health services research (HSR) involving medical decision-making and health information technology to improve quality of health care.

Health services research in primary care and geriatrics applying health informatics for quality improvement in health care. The ATHENA-Clinical Decision Support (CDS) project develops knowledge-based systems for application to patient data in electronic health records (EHR) and presentation of findings and recommendations to health professionals within the EHR. Current work in this project includes knowledge engineering of knowledge bases to expand the library of encoded clinical guidelines; evaluation of existing systems based on stakeholder input; integrating CDS into the clinician dashboard to support Patient-Aligned Care Teams (PACTS; akin to PCMH) for Department of Veterans Affairs; and using encoded knowledge to automate clinically-relevant performance metrics using EHR data.

Other work includes extracting information from free-text of the EHR using natural language processing; developing methods to incorporate quality of life information into cost-effectiveness analyses for health care of older adults; and collaborating on conceptual framework for decision complexity for patients with multimorbidity.