2023 Undergraduate Summer Research Program Participant

Home Department: undeclared
Mentor: Jonathan Lin (Pathology and Ophthalmology)

“Testing Anti-Tau Properties of Small Molecule Integrated Stress Response Boosters”

Soyeon’s project aims to investigate the potential of small molecules to prevent the accumulation of tau protein in the brain, which is associated with neurodegenerative diseases like Alzheimer’s Disease. The project focuses on the Integrated Stress Response (ISR), a critical mechanism for maintaining protein quality control in cells. The Lin lab has identified small molecules that boost the function of ISR and prevent tau buildup. To assess their effectiveness in preventing memory loss, Soyeon will administer these ISR boosters to mice with tau-related neurodegeneration and will use behavioral tests to evaluate memory performance and analyze brain tissue to assess cell death and tau levels. The study will help gain a comprehensive understanding of the underlying pathology of neurodegenerative diseases and explore potential therapeutic approaches at the molecular and behavioral levels.