Home Department: Bioengineering and Chemistry
Mentor: Fan Yang (Orthopaedic Surgery and Bioengineering)

“A Tissue-Engineered 3D Triculture Model Simulating Breast-Cancer Bone Metastasis for Drug Screening”

Breast cancer-bone metastasis affects over 65% of advanced cases, leading to severe complications. This project aims to develop a spatially-patterned 3D triculture model mimicking human bone and breast cancer interaction to study metastasis-inhibiting drugs. Using various pre-clinically established targeted and endocrine drugs, Vedant will demonstrate the utility of the model in testing drug efficacy on immortalized cancer cell lines (MDA-MB-231, MCF-7), by studying the impact of these treatments on cancer cell proliferation, invasion, survival, and bone remodeling dysregulation. This model could serve as a useful platform to pinpoint new effective treatments for inhibiting metastasis, addressing gaps in current therapeutic strategies.