2012 Undergraduate Summer Research Program Participant

Home Department: Biological Chemistry
Supported by: Steve Krausz and Marisa Arredondo
Mentor: Gerald Crabtree, Professor of Experimental Pathology and, of Developmental Biology

Victoria is a rising junior from Maryland working in Dr. Gerald Crabtree’s lab this summer. Previous work from the Crabtree lab has demonstrated that human astrocytes may be directly converted to neurons upon over-expression of two specific microRNAs. This summer, she is developing a dual reporter assay using time-lapsed fluorescence images of individual cells to monitor the conversion process at the single cell level. She is very interested in developmental biology and plans to pursue either a graduate degree in biology or a medical degree after graduation.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 27, 2012:

Direct Conversion of Astrocytes to Neurons through Overexpression of MicroRNAs at the Single Cell Level

Victoria Chang1,2, Alfred Sun1,2, Gerald Crabtree1,2
[Howard Hughes Medical Institute1and Department of Developmental Biology2, Stanford University]