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W. E. Moerner - Harry S. Mosher Professor and Professor of Chemistry and (by courtesy) of Applied Physics

Bio-X Affiliated Faculty

Dr. Moerner's Laboratory utilizes laser spectroscopy and microscopy of single molecules to probe biological processes, one biomolecule at a time.  Primary thrusts include development and application of fluorescence microscopy far beyond the optical diffraction limit by PALM/STORM and STED approaches, invention and validation of methods for precise and accurate 3D optical microscopy in cells, and trapping of single biomolecules in solution for extended study.  These approaches are applied to explore protein localization patterns in bacteria, to measure structures of amyloid aggregates in cells, to the behavior of signaling proteins in the primary cilium, and to the dynamics of DNA and RNA in cells and viruses.