Dr. Wong's lab develops methods in multivariate analysis, machine learning, Monte Carlo, differential equations and high performance computing, and apply them to problems in computational biology and personalized medicine.

They developed the software dChip for the analysis microarray data and the programs CisGenome, SeqMap and SpliceMap for the analysis of next generation sequencing data. Their methodological work is motivated by close collaborations with biology groups on problems arising from cancer and developmental biology. Of particular interest is the combined use of experimental and computational analysis to clarify the cis-regulatory mechanisms underlying several developmental processes. More generally, they employ and develop tools from exploratory data analysis, multivariate analysis, information theory, machine learning, Monte Carlo, graph theory, linear and nonlinear differential equations, and applied them to problems in computational biology and system biology.