Bio-X SIGF Graduate Student Fellow

Awarded in 2018
Home Department: Bioengineering
Faculty Advisors: Stephen Quake (Bioengineering and Applied Physics) and John Boothroyd (Microbiology & Immunology)

Research Title: Single-cell profiling of host-pathogen interactions

Research Description: Toxoplasma gondii is a harmful and widespread intracellular human parasite that transitions between virulent and dormant stages. Understanding the effect of Toxoplasma infection on the human brain requires measurement of dynamical changes Photo of graduate student Yuan Xue in the lab, putting samples into a piece of both the host cells and the parasite. Single-cell transcriptome sequencing offers a powerful approach to investigate the transcriptional response of infected neurons over the course of Toxoplasma stage conversion. Yuan will apply single-cell sequencing to determine a co-transcriptomic map of host-parasite interactions and answer key questions about the neurological effects of Toxoplasma infection. This multidisciplinary project of high-throughput measurements, bioinformatics, microbiology and immunology will facilitate the means to combat Toxoplasma infection.


Yuan is a bioinformatics scientist that leads process optimization at ClearNote Health.